在多发性骨髓瘤中异性干细胞移植的长期结果
Walker M Schmidt1, Nirosha D Perera2, Francis K Buadi3
1Alix School of Medicine, Mayo Clinic, Rochester, MN, USA. schmidt.walker@mayo.edu.
Blood cancer journal
|August 17, 2023
概括
针对多发性骨髓瘤 (MM) 的全基性干细胞移植 (allo SCT) 显示出不良的长期结果,与高治疗相关的死亡率和复发率. 与MM患者的SCT相比,新的治疗方法可能提供更好的耐受性和有效性.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 干细胞移植 干细胞移植
背景情况:
- 全基性干细胞移植 (allo SCT) 是多发性骨髓瘤 (MM) 的治疗方法,但其治愈潜力与显著的毒性相平衡.
- 在MM的SCT分配后,患者的结果和预后因素需要进一步调查.
研究的目的:
- 追溯分析多发性骨髓瘤 (MM) 患者的结局,这些患者接受了全源干细胞移植 (allo SCT).
- 确定与MM的SCT分配后的长期存活相关的预后标志物.
主要方法:
- 在2000年至2022年期间,85名MM患者接受了SCT的回顾性分析.
- 卡普兰-梅尔方法和竞争风险模型用于估计整体生存 (OS),无进展生存 (PFS),与治疗相关的死亡率 (TRM) 和复发率 (RR).
主要成果:
- 平均OS和PFS分别为1.7年和0.71年;5年的OS和PFS分别为22.2%和15.1%.
- 一年的TRM为23.5%,大多数患者在2年内复发或死亡.
- 持久生存 (10年以上) 与较少的先前自身SCT和较早的移植时代 (2000-2010年) 相关.
结论:
- 在这个队列中接受SCT的多发性骨髓瘤患者的结果很差,长期存活率有限,早期死亡率高.
- 这项研究表明,与MM的SCT相比,新型疗法可能会提供更好的结果和耐受性.
- 鉴于观察到的毒性和aloSCT的有限疗效,对替代治疗策略的进一步研究是有必要的.
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