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Updated: Jul 19, 2025

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在小细胞肺癌中,KDM6A在表观遗传学上调节亚型可塑性

Leslie Duplaquet1, Yixiang Li1, Matthew A Booker2

  • 1Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Nature cell biology
|August 17, 2023
PubMed
概括

由于KDM6A的不活化导致小细胞肺癌 (SCLC) 的可塑性从ASCL1转变为NEUROD1亚型. 这种表观遗传调节影响SCLC异质性,为这种具有挑战性的癌症的治疗策略提供了洞察力.

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