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在LIFU刺激中计算建模和最小化意外的神经元激发

Boqiang Fan1, Wayne Goodman2,3, Raymond Y Cho3

  • 1Department of Electrical and Computer Engineering, Rice University, Houston, TX, 77005, USA. Boqiang.Fan@rice.edu.

Scientific reports
|August 17, 2023
PubMed
概括

低强度聚焦超声波 (LIFU) 神经调节可以导致无意的神经刺激. 一个新的计算模型和光束成形方法 (CORB) 显著减少了目标外激活,提高了临床应用的安全性.

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A postsynaptic neuron usually receives numerous impulses from several other presynaptic neurons. The axon hillock of the postsynaptic neuron integrates all these signals and determines the likelihood of firing an action potential.
Sometimes a single EPSP is strong enough to induce an action potential in the postsynaptic neuron. However, multiple presynaptic inputs must often create EPSPs around the same time for the postsynaptic neuron to be sufficiently depolarized to fire an action potential.