艾滋病毒/结核病同时感染的代谢后果
Chandré Herbert1, Laneke Luies1, Du Toit Loots1
1Human Metabolomics, North-West University, Potchefstroom, South Africa.
BMC infectious diseases
|August 17, 2023
概括
人类免疫缺陷病毒 (HIV) 和结核病 (TB) 的同时感染会破坏宿主新陈代谢,改变脂质和蛋白质特征. 抗逆转录病毒疗法 (ART) 在同时感染的患者中部分逆转了这些代谢变化.
科学领域:
- 代谢学 代谢学 代谢学
- 传染病的发病因子 传染病的发病因子
- 艾滋病毒/结核病并发感染
背景情况:
- 导致艾滋病毒/结核病 (TB) 共感染的代谢相互作用尚不清楚.
- 抗艾滋病毒治疗 (ART) 可以导致超出感染或疾病的代谢干扰.
研究的目的:
- 为了研究HIV/TB同时感染的血清代谢概况.
- 了解抗逆转录病毒疗法 (ART) 对这些代谢变化的影响.
主要方法:
- 使用2D GC-TOF-MS分析了血清代谢概况.
- 与健康对照组,未经治疗的结核病,未经治疗的艾滋病毒/结核病和接受ART治疗的HIV/结核病患者进行了比较.
主要成果:
- 艾滋病毒/结核同时感染改变了脂质和蛋白质代谢,并增加了微生物转移.
- 艾滋病毒通过增加炎症,氧化应激和ART诱导的线粒体损伤影响肠道健康和能量来加剧结核病.
- ART 部分恢复了新陈代谢概况,但没有恢复到健康的对照水平.
结论:
- 艾滋病毒/结核病联合感染显著影响宿主新陈代谢.
- 在同时感染的个体中,ART提供了部分代谢恢复.
- 为未来的艾滋病毒/结核病代谢研究提出假设.
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