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局部发达的胸腺瘤;新辅助化疗是否有所不同?

Riad Abdel Jalil¹, Farah A Abdallah², Zeinab Obeid²

¹Department of Thoracic Oncology, King Hussein Cancer Center, Queen Rania Al Abdullah Street, P.O. Box 1269, Amman, 11941, Jordan. Da.06648@khcc.jo.

Journal of cardiothoracic surgery

|August 17, 2023

概括

针对局部晚期胸腺瘤的新辅助化疗 (NACT) 显示了极小的放射和病理效应. 与前期手术相比,这种方法并没有显著改善瘤结果,而NACT组的复发风险更高.

科学领域:

在瘤学瘤学.
胸部外科手术胸部外科手术
癌症研究癌症研究

背景情况:

胸腺瘤是最常见的前中的原发性瘤.
手术切除 (胸膜切除术) 是胸膜瘤的主要治疗方法.
新辅助化疗 (NACT) 被认为是局部晚期或边界切除性胸腺瘤,以提高R0切除率.

研究的目的:

评估新辅助化疗 (NACT) 在局部晚期胸腺瘤的疗效和安全性.
用放射学和病理学标准评估NACT对瘤负担的影响.
为了比较接受NACT和接受前期手术的患者之间的瘤结果.

主要方法:

在2015-2021年期间治疗的23名胸腺瘤患者的回顾性分析.
使用CT扫描和RECIST标准评估瘤负担.
通过测量瘤死的百分比来评估病理反应.

主要成果:

NACT对瘤负担的影响很小 (8/12名患者的RECIST稳定疾病).
平均瘤缩率为39.5%,瘤体积没有显著变化.
与前期手术相比,NACT组的复发率更高 (33.3%) 和平均存活时间更短 (43.8个月).

结论:

与前期手术相比,NACT并没有显著改善局部晚期胸腺瘤的瘤结果.
放射学和病理学评估表明,NACT的益处很小.
建议进行多中心研究,以进一步澄清诱导化疗的作用.

关键词:

组织病理学影响组织病理学影响新辅助化学疗法新辅助化学疗法射线图形效应射线图形效应射线图形效应胸腺瘤是什么意思胸腺瘤是什么意思

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