有效和有效地使用皮性尿路标记物的有效和有效使用
Jared M Whitson1, Sima P Porten2, Ahmed A Hussein3
1Department of Urology, Kaiser Permanente South Sacramento Medical Center, Sacramento.
Urology practice
|August 18, 2023
概括
尿路标记器有助于诊断和监测膀癌,但不是用于查. 一个负标记可以减少一些患者的囊镜检查,而严重的血仍然保证了手术.
科学领域:
- 尿瘤学 尿瘤学
- 生物标志物研究的研究.
- 临床诊断 临床诊断 临床诊断
背景情况:
- 皮性尿路标记物被广泛使用,但缺乏基于证据的应用指南,用于膀癌的检测和监测.
- 现有的数据和审查还没有为将这些工具纳入临床实践建立一个明确的框架.
研究的目的:
- 为在膀癌中尿路标记物的临床应用提供基于证据的框架.
- 引导临床医生使用这些工具进行膀癌风险评估,诊断和监测.
主要方法:
- 自2003年以来,对空白的尿路标记物用于膀癌的英语文献进行系统审查.
- 分析敏感性和特异性数据,用于查,血评估和诊断后监测.
- 应用统计工具和成本效益分析来制定建议.
主要成果:
- 尿路标记在膀癌查中没有作用,因为其患病率很低.
- 阴性尿路标志物可能可以在微观出血症病例中避免囊囊镜检查.
- 大型出血需要囊镜检查,不论标记物结果如何.
- 负标记可能允许低风险膀癌患者的囊镜检查频率较低.
结论:
- 排卵性尿路标志物在膀癌的诊断和监测中具有明确的作用.
- 提出了一种基于证据的实用方法,用于例行临床应用.
- 需要进行进一步的研究,以开发具有成本效益的算法和新的标记物.
相关概念视频
Urine Studies I: Urinalysis
40
Urinalysis is a widely used diagnostic test that analyzes urine's physical, chemical, and microscopic characteristics. Healthcare providers use it to detect and monitor various health conditions, including renal disease, urinary tract infections (UTIs), diabetes, and metabolic or systemic disorders.Components of UrinalysisUrinalysis consists of three primary components: physical, chemical, and microscopic examination. Each provides unique insights into the urine sample and, by extension, the...
40
One-Compartment Open Model: Urinary Excretion Data and Determination of k
219
The one-compartment open model leverages urinary excretion data to estimate renal clearance, which gauges the kidney's capacity to expel a drug. This method offers several benefits, including directly measuring drug elimination and assessing the kidney's contribution to overall drug clearance. However, this approach has limitations. It assumes sole renal excretion of the drug, which is not true for all drugs. Accurate urinary excretion and plasma drug concentration measurement can also...
219
Urine Studies II: Urine Culture and Sensitivity Test
54
A urine culture and sensitivity test is a diagnostic procedure used to identify urinary tract bacterial infections and determine the most effective antibiotics for treatment. This test is generally preferred when a patient shows manifestations of a urinary tract infection, such as frequent or painful urination, cloudy or foul-smelling urine, or lower abdominal pain.Purpose of the TestThe primary goals of a urine culture and sensitivity test are to:Determine the specific bacteria causing the...
54
Urinary Tract Calculi III: Medical Management
9
The diagnosis of renal calculi involves several imaging techniques, including non-contrast CT scans and ultrasound. These methods help visualize kidney stones, assess their size and location, and detect possible obstructions. Additionally, Measuring urine pH is useful for diagnosing specific stone types, such as struvite (alkaline pH) and uric acid stones (acidic pH). Cystine stones are primarily linked to cystinuria, a genetic condition. A urinalysis helps detect blood in the urine (hematuria)...
9
Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care
15
A healthcare provider can diagnose a urinary tract infection (UTI) through several methods:Medical History and Symptoms: The provider will take a detailed medical history and ask about symptoms such as frequent urination, burning sensation during urination, and lower abdominal pain.Urinalysis: A clean-catch urine sample is collected in a sterile container and tested for the presence of bacteria, white blood cells (leukocytes), nitrites, blood, and protein. The presence of leukocytes and...
15
Urinary Tract Infection IV: Nursing Management
24
In managing urinary tract infections (UTIs) in nursing, a comprehensive assessment is essential. Begin by gathering subjective data, such as the patient’s complaints of dysuria (painful urination), urinary frequency, urgency, suprapubic pain, and any lower abdominal discomfort. This information can be complemented by questions regarding previous UTIs, sexual activity, and personal hygiene practices, which can provide insight into risk factors. Objective assessment should focus on signs...
24


