菌毒素和肌缩侧面硬化症:食物暴露,营养影响和饮食解决方案
Umberto Manera1,2, Enrico Matteoni1, Antonio Canosa1,2,3
1ALS Centre, "Rita Levi Montalcini" Department of Neuroscience, University of Turin, Turin, Italy.
CNS & neurological disorders drug targets
|August 18, 2023
概括
长期暴露于真菌的天然毒素 - - 菌毒素,可能在神经退行性疾病,如肌缩性侧面硬化症 (ALS) 中发挥重要作用. 需要进一步的研究来了解它们的影响和减轻风险.
科学领域:
- 环境毒理学环境毒理学
- 神经科学是一个神经科学.
- 菌类学 菌类学是指菌类学.
背景情况:
- 肌缩侧面硬化症 (ALS) 是一种复杂的神经退行性疾病,受遗传和环境因素的影响.
- 慢性低剂量环境污染物暴露,特别是真菌毒素在神经退行症中的作用仍未得到充分研究.
- 最近真菌生物学方面的进步增加了对菌毒素的关注.
研究的目的:
- 审查现有的关于与全球ALS爆发相关的环境暴露的文献.
- 根据新的科学发现,重新评估菌毒素在ALS和其他神经退行性疾病中的潜在作用.
- 确定当前研究中存在的空白,这些空白低估了真菌毒素作为有害物质的价值.
主要方法:
- 对环境暴露导致ALS爆发的研究进行系统审查.
- 分析最近关于神经退行性疾病中食源性真菌毒素暴露,真菌生物组和真菌感染的研究.
- 确定关键的真菌毒素及其受影响的生物通路.
主要成果:
- 经常被忽视的真菌毒素可能会对神经退行产生重大影响.
- 慢性,低剂量菌毒素暴露在ALS和相关疾病的流行病学研究中值得考虑.
- 已经确定了受菌毒素影响的特定生物途径.
结论:
- 菌毒素在像ALS这样的神经退行性疾病中具有潜在的重要,但被低估的因素.
- 结合菌毒素评估的进一步流行病学研究至关重要.
- 科学家和政策制定者之间的协作努力对于开发干预措施和通过饮食多样性促进健康至关重要,以减轻菌毒素暴露风险.
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