在阿波利波蛋白E缺乏的小鼠中,NAD+ 保护抗高脂血症诱导的损伤
Zuowei Pei1,2, Yu Li3, Wei Yao3
1Department of Cardiology, Central Hospital of Dalian University of Technology, Dalian, 116033, China.
Current pharmaceutical biotechnology
|August 18, 2023
概括
尼古丁胺胺氨基二核酸 (NAD+) 补充剂可能会防止高脂血症诱导的损伤. 在高胆固醇饮食的小鼠中,NAD+治疗减少了氧化应激,改善了代谢参数.
科学领域:
- 生物化学 生物化学
- 腎臟病學 (nephrology) 是一種醫學.
- 代谢疾病 代谢疾病
背景情况:
- 超脂血是造成损伤的重要危险因素.
- 尼古丁胺胺氨基二核酸 (NAD+) 是细胞代谢中的关键辅酶.
- 了解NAD+在代谢障碍中的作用对于治疗的发展至关重要.
研究的目的:
- 为了研究NAD+对高脂血症诱导的损伤的保护作用.
- 在小鼠模型中评估NAD+对代谢参数和病理的影响.
- 探索NAD+的保护潜力的基础分子机制.
主要方法:
- 缺乏阿波利波蛋白E (ApoE-/-) 的小鼠被食正常或高脂肪饮食 (HFD),并或未补充NAD+16周.
- 评估了代谢参数,包括脂质,肌和血液尿素.
- 脏组织通过组织学和西班牙血清分析氧化应激和纤维化标志物.
主要成果:
- HFD显著提高了新陈代谢参数,并诱导脏损伤.
- 在HFD小鼠中补充NAD+可降低氧化应激标志物 (NRF2,SOD2) 和纤维化标志物 (TGF-β,原I/III).
- 在HFD小鼠中,NAD+增加了抗亡蛋白 (Bcl-2,Bcl-xL) 和减少了亲亡蛋白 (Bax,Bak).
结论:
- 在高脂血症引起的损伤中,NAD+显示出显著的保护作用.
- 补充NAD+可以减轻氧化应激,纤维化和脏的亡.
- NAD+作为治疗超脂血症相关脏疾病的潜在治疗剂具有前景.
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