在美国一般人口中探索脂肪性肝病的风景
Stefano Ciardullo1,2, Marco Carbone3,4, Pietro Invernizzi3,4
1Department of Medicine and Rehabilitation, Policlinico di Monza, Monza, Italy.
概括
脂肪性肝病 (SLD) 的新定义表明,代谢功能障碍在美国很常见. 这种诊断更新并没有显著改变SLD的总体患病率.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 脂肪性肝病 (SLD) 是一个日益严重的健康问题.
- 目前SLD的诊断标准正在发展.
- 一个多社会德尔菲共识声明提出了新的SLD定义.
研究的目的:
- 评估新的多社会SLD定义的流行病学影响.
- 根据新的标准,评估SLD亚型的流行程度.
- 确定美国人口中满足SLD代谢功能障碍标准的比例.
主要方法:
- 使用2017-2020年国家健康和营养检查调查数据进行横截面研究.
- 用振动控制的短暂弹性图用于肝脏脂肪和纤维化评估.
- 适用于新陈代谢功能障碍相关的脂肪性肝病 (MASLD),MetALD,MASLD-病毒性肝病和酒精性肝病 (ALD) 的新标准.
主要成果:
- 在美国42.1%的成年人中存在SLD.
- 几乎所有的SLD病例 (99.4%) 都符合代谢功能障碍的定义.
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 占SLD病例的89.4%;在MASLD患者中观察到15.2%的显著纤维化.
结论:
- 代谢功能障碍在患有SLD的美国成年人中非常普遍.
- 更新的诊断标准并没有实质性地改变SLD的总体患病率.
- 新的定义与以前的代谢功能障碍相关的脂肪肝疾病标准密切结合.
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