癌症患者因COVID-19住院后的间歇性肺部异常:一项前性队列研究
Sungryong Noh1, Christopher Bertini2, Isabel Mira-Avendano1
1Division of Critical Care, Pulmonary and Sleep Medicine, McGovern Medical School, Houston, Texas, USA.
患有COVID-19肺炎的癌症患者经常出现持续的间歇性肺异常 (ILA). 较高的肺炎严重性得分和年龄较大预测正在进行的ILA,突出显示免疫受损人群的风险.
科学领域:
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
- 在瘤学瘤学.
背景情况:
- 患有SARS-CoV-2肺炎的幸存者通常会经历持续的呼吸道症状和间歇性肺异常 (ILA).
- 在免疫功能低下的个体,如癌症患者中,ILAs的风险因素和持续时间尚不清楚.
研究的目的:
- 为了调查COVID-19肺炎后癌症患者中ILAs的发生率和预测因素.
- 评估呼吸道症状和ILA在出院后3个月和6个月的持续性.
主要方法:
- 140名患有COVID-19肺炎的癌症患者的前性队列研究.
- 收集的临床和放射数据,包括放射性严重性指数 (RSI).
- 在出院3个月和6个月后使用CT扫描,PFT和症状评估进行肺部评估.
主要成果:
- 70%的癌症患者在3个月后有ILA,26%的患者在6个月后仍然有持续的ILA.
- 在住院期间高峰RSI预测了3个月和6个月的ILA.
- 纤维化ILA在出院6个月后更为普遍.
结论:
- 在COVID-19后的ILA在癌症患者中很常见.
- 峰值RSI和年龄较大是持续性ILA的重要预测因素.
- 调查结果强调需要监测和管理这个脆弱群体的呼吸道并发症.
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