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Updated: Jul 19, 2025

Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines
05:07

Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines

Published on: June 23, 2019

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酸乙胺作为合成平台,用于合成阿米诺皮拉衍生物

Valeriy O Filimonov1,2, Alexandra I Topchiy1, Vladimir G Ilkin1

  • 1Technology of Organic Synthesis Department, Ural Federal University named after the first President of Russia B. N. Yeltsin, 19 Mira st. Yekaterinburg 620002, Russia.

Beilstein journal of organic chemistry
|August 18, 2023
PubMed
概括

这项研究探讨了蓝胺与氨酸的反应,形成二氨基甲醇. 一种新的合成产生了1-替代-4-thiocarbamoyl pyrazoles,其结构通过光谱学和X射线分析得到证实.

关键词:
2 - 氨基乙胺二氧化.亚米诺皮拉醇是一种氨基酸.酶氨酸是一种胺.含有酸盐的酸盐.

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Azide ions act as good nucleophiles and react with unhindered alkyl halides to form alkyl azides. Alkyl azides do not participate in further nucleophilic substitution reactions, thereby eliminating the chances of polyalkylated products. Alkyl azides are reduced by hydride-based reducing agents, like lithium aluminum...
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In the presence of an aqueous base and a halogen, primary amides can lose the carbonyl (as carbon dioxide) and undergo rearrangement to form primary amines. This reaction, called the Hofmann rearrangement, can produce primary amines (aryl and alkyl) in high yields without contamination by secondary and tertiary amines.
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