在综合性癌症中心的非爆发环境中,Clostridioides difficile分离物的分子流行病学
Neha Mehta1, Jennifer M Harrington2, Meghan A Wallace3
1Internal Medicine Residency Program, Jacobs School of Medicine and Biomedical Sciences, State University of New York, Buffalo, NY, USA.
Antimicrobial stewardship & healthcare epidemiology : ASHE
|August 18, 2023
概括
在癌症患者中,核型鉴定确定了14种Clostridioides difficile核型,其中大多数菌株属于六种常见类型. 一个新型的核型携带了二进制毒素基因,表明了这一群体中潜在的毒性因素.
科学领域:
- 微生物学 微生物学
- 在瘤学瘤学.
- 传染性疾病 传染性疾病
背景情况:
- 艰难结肠杆菌感染 (CDI) 是患有恶性瘤的患者的一个重大问题,往往导致严重的结肠炎.
- 了解这种免疫受损人群中C. difficile分离体的基因型多样性对于感染控制和治疗策略至关重要.
研究的目的:
- 从患有大肠炎的恶性瘤患者中获得的Clostridioides difficile分离物的核型的特征.
- 为了在这个特定的患者队列中识别流行和新兴的核型.
主要方法:
- 型鉴定用于分析从111次癌症患者大肠炎发作中收集的Clostridioides difficile分离物.
- 隔离物被根据它们的核糖型简介分类.
主要成果:
- 总共有31个C. difficile分离物 (27.9%的发作) 被恢复,代表14个不同的核型.
- 大多数的分离物,25 (80.6%),属于六种常见的核型:014/020,1/VPI/077/087,05/015,015/046,05/053和106/174.
- 鉴定出了三种新型的核糖型,其中一种分离物具有编码二进制毒素的基因.
结论:
- 在患有大肠炎的癌症患者中,C. difficile的基因型格局主要由少数流行的核型构成.
- 新型核糖类型的出现,特别是具有二进制毒素基因的核糖类型,需要进一步调查其临床意义和对这种脆弱群体疾病严重程度的潜在影响.
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