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Quantitative Autonomic Testing
Published on: July 19, 2011
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综合自主症状得分31问卷:检测自主神经病变风险的敏感测试
Sondre Meling1,2, Erling Tjora2,3, Heike Eichele4,5
1Department of Medicine, Stavanger University Hospital, Stavanger, Norway.
Journal of diabetes research
|August 18, 2023
概括
综合自主症状评分 (COMPASS) 31有效评估挪威糖尿病患者的自主神经病变. 将COMPASS 31得分值降至10提高了糖尿病自主神经病变的查灵敏度.
科学领域:
- 神经学 神经学
- 内分泌学 在内分泌学.
- 糖尿病学 糖尿病学
背景情况:
- 自主神经病是糖尿病,糖尿病前期和糖尿病风险升高的常见并发症.
- 综合自主症状评分 (COMPASS) 31是评估自主症状的验证工具.
- 早期发现和管理自主神经病变对于预防长期并发症至关重要.
研究的目的:
- 评估COMPASS 31调查问卷的挪威数字版本的可行性.
- 调查COMPASS 31分数在已建立的糖尿病神经病症测试中区分积极和消极结果的能力.
- 探索COMPASS 31在评估心血管自主神经病变 (CAN) 和胃肠内脏敏感性方面的实用性.
主要方法:
- 包括21名长期患有2型糖尿病的参与者,15名早期患有2型糖尿病的参与者和30名健康对照.
- 表型包括心血管自主反射测试,皮肤电导率,外围神经电生理学和单丝测试.
- 胃肠内脏和自主神经功能通过在直肠气球膨胀后唤起的潜能来评估.
主要成果:
- 患有长期糖尿病 (14.9分) 和确定的/边缘CAN (14.3分) 的参与者在COMPASS 31上比早期糖尿病 (7.3分) 和没有CAN (8.3分) 组得分更高.
- 女性得分明显高 (14.4分) 比男性 (7.8分).
- 将COMPASS 31的诊断切线从16降低到10,使灵敏度从33%提高到83%,但使特异性从68%降低到55%.
结论:
- 挪威数字COMPASS 31是可行的,并推用于自主神经病变的临床评估.
- 长期存在的糖尿病与自主神经病变症状和征兆的可能性更高有关.
- 减少10分的COMPASS 31切线提高了自主神经病变的查灵敏度,较低的分数几乎排除了诊断.
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