红皮质牛皮症中的心力衰竭:对225名患者的回顾性研究
Chao Wu1, Chenyang Yu1, Yuyan Yang1
1Department of Dermatology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases, Beijing, China.
Frontiers in cardiovascular medicine
|August 18, 2023
概括
皮质上皮 psoriasis (EP) 显著增加心力衰竭的风险,特别是在患有并发症的老年患者中. 在EP患者中纤维细胞生长因子23 (FGF23) 水平升高表明其在心血管并发症中的作用.
科学领域:
- 心脏病学 心脏病学
- 皮肤病学 皮肤病学
- 生物化学 生化学
背景情况:
- 红皮质牛皮 (EP) 是一种严重的皮肤病,具有全身影响.
- 心血管参与PE是公认的,但研究不足.
- 纤维细胞生长因子23 (FGF23) 与慢性心力衰竭有关,但其在EP中的作用尚不清楚.
研究的目的:
- 为了确定心力衰竭在患有皮质皮质牛皮 (EP) 的患者中的患病率.
- 为了确定与EP患者心力衰竭相关的因素.
- 测量纤维细胞生长因子23 (FGF23) 的血清度,作为EP中心力衰竭的潜在预测因子.
主要方法:
- 在2005-2021年期间住院的225名EP患者的回顾性研究.
- 对心力衰竭患病率和相关临床因素的分析.
- 使用ELISA测量了17名EP患者和8名健康对照者的血清FGF23水平.
主要成果:
- 在EP患者中,心力衰竭被诊断为11.1%.
- 与心力衰竭相关的因素包括年龄,冠状动脉心脏病史,发烧,感染,hsCRP升高,贫血,低albuminemia和超脂血.
- 在EP患者中,血清FGF23水平明显高于对照组,并在治疗后降低.
结论:
- EP患者,特别是患有并发症和全身炎症的老年人,面临心力衰竭的风险增加.
- 在EP患者中FGF23水平升高可能表明与心血管并发症的联系.
- 对心力衰竭的认识和监测对于管理EP患者至关重要.
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