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富含植物性大麻素的局部用制剂:提取和稳定性测试

Dominika Kaczorová^1,2,3, Jaroslav Peč⁴, Tibor Béres¹

¹Czech Advanced Technology and Research Institute, Palacký University, Olomouc, Czechia.

Frontiers in pharmacology

|August 18, 2023

概括

这项研究开发了一种快速,标准化的协议,用于准备医用大麻局部配方. 橄油和辛德曼基显示出高大麻素提取和稳定性,解决了皮肤病学使用的关键障碍.

科学领域:

皮肤病学皮肤病学
药理学药理学是指药理学的学科.
盖伦尼克药房盖伦尼克药房

背景情况:

捷克医学大麻合法化 (2013) 允许用于皮肤疾病的局部治疗.
医用大麻性配方的有限实施归因于缺乏标准化的制备方案.
像大麻 (CBD) 和四大麻 (THC) 这样的大麻素显示出治疗潜在的疾病,包括亚托皮炎,牛皮和.

研究的目的:

评估各种制药基的大麻素提取能力.
为了评估皮肤病学用途的制备的基配方中的大麻素的稳定性.
为药房和医疗机构提出一个标准化,易于实施的准备协议.

主要方法:

评估了不同制药基因对大麻素的提取效率.
随着时间的推移,监测了基配方中的四大麻 (THC) 和大麻 (CBD) 的稳定性.
的物理和化学特性与大麻素的稳定性和提取相关.

主要成果:

配方中的大麻素稳定性取决于基的特性.
最高的THC分解发生在奶油基 (高达5.4%/周) 和瓦斯林 (高达5.6%/周).
CBD表现出比THC更大的稳定性;橄油和辛德曼基表现出最高的提取率 (约. 70%) 和稳定性.

结论:

为医用大麻局部配方提出了一个快速且易于实施的准备协议.
橄油和辛德曼基被推用于皮肤学制剂的最佳大麻素提取和稳定性.
标准化协议对于医用大麻在皮肤疾病医疗保健中的更广泛实施至关重要.

关键词:

大麻树种L.大麻树种L.皮肤学皮肤学提取物提取物提取物素制剂的制备医用大麻医疗大麻的使用这是一种植物性大麻素 (phytocannabinoid).稳定的稳定性稳定的稳定性局部应用局部应用

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