在COVID-19患者中醒来易患位定位:系统性审查和元分析
Agustin García1, Rita Galeiras1, Sonia Pertega-Díaz2
1A Coruna University Hospital, A Coruña, Spain.
概括
醒着的倾向性定位显著降低了SARS-CoV-2患者的死亡率. 虽然整体上没有统计学意义,但它降低了对内内管道输入的需求,特别是在随机试验中.
科学领域:
- 关键护理医学 关键护理医学
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
背景情况:
- 目前对SARS-CoV-2低氧患者的清醒倾向定位的建议是基于对一般呼吸困扰的研究.
- 对于COVID-19患者的倾斜定位的具体好处需要进一步调查.
研究的目的:
- 在SARS-CoV-2患者中,系统地审查和元分析清醒易感定位对氧化,内管道输管 (ETI) 和死亡率的影响.
- 评估倾斜定位在改善COVID-19患者呼吸系统结果中的有效性.
主要方法:
- 从2020年6月到2021年11月,对PubMed和Embase数据库进行了系统的搜索.
- 进行了一项随机效应的元分析,以评估的对ETI和死亡率的影响.
- 进行了分组分析,包括随机临床试验 (RCT).
主要成果:
- 在接受倾斜定位的患者中观察到死亡率显著降低 (RR = 0.69; 95% CI: 0.480.99; p = 0.044).
- 没有发现对ETI需要的总体显著影响 (RR=0.79;95%CI:0.631.00;p=0.051).
- 对RCT的子组分析显示,对ETI的需求显著下降 (RR = 0.83;95%CI:0.710.97).
结论:
- 清醒的倾向性定位显著降低了SARS-CoV-2患者的死亡率.
- 倾斜的位置可能会减少对内内管管道的需求,特别是当早期实施和与非侵入性通风或高流量鼻治疗一起实施时.
- 在RCT的子组分析中,ETI的减少在统计学上显著,突出了其潜在的益处.
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