一个多中心评估Streptococcus pneumoniae隔离物中的整体敏感性和抗菌耐药性
Namrata Kulkarni1, Abhisek Routray1, Santosh Taur1
1Department of Medical Affairs, Pfizer Limited, Mumbai, IND.
Cureus
|August 18, 2023
概括
在印度,Streptococcus pneumoniae的抗菌素耐药性是越来越令人担忧的. 这项研究观察到对青素和类胺的耐药性日益增加,突出显示了对新疫苗和管理的需求.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 肺炎链球菌是全球主要的死亡原因.
- 抗菌素耐药性 (AMR) 对公众健康构成重大威胁.
- 抗微生物检测领导和监测 (ATLAS) 计划监测抗菌耐药性趋势.
研究的目的:
- 评估印度Streptococcus pneumoniae分离物的抗微生物敏感性 (AMS).
- 从2018年到2021年分析肺炎球菌耐药性的趋势.
- 为打击肺炎球菌感染的策略提供信息.
主要方法:
- 从2018年至2021年收集非重复的临床显著的S. pneumoniae分离物.
- 在实验室使用微稀释方法进行敏感性测试.
- 遵守临床和实验室标准研究所 (CLSI) 的指导方针.
主要成果:
- 从2018年到2020年,观察到S. pneumoniae分离体的显著增加.
- 对红红素,勒沃素,梅罗和青素的敏感性显著下降.
- 克林达米辛的敏感性也下降了,而线利德和万科米辛保持了100%的敏感性.
结论:
- 在印度,S. pneumoniae中对青素和类的耐药性增加.
- 建议使用具有更广泛血清型覆盖的肺炎球菌结合疫苗 (PCV).
- 有针对性的抗微生物药物管理对于管理不断上升的耐药性率至关重要.
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