长度研究表观遗传衰老及其与大脑衰老和年轻成人认知能力的关系
Klara Mareckova1,2, Anna Pacinkova1,3, Radek Marecek1
1Brain and Mind Research, Central European Institute of Technology (CEITEC), Masaryk University (MU), Brno, Czechia.
Frontiers in aging neuroscience
|August 18, 2023
概括
在年轻人中,表观遗传年龄差距 (EpiAGE) 稳定,但与大脑衰老的联系有限. 在女性中,较高的EpiAGE与加速的大脑衰老和较低的智商有关.
科学领域:
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 神经科学是一个神经科学.
- 老年学是指老年学的学科.
背景情况:
- 由于老年人比例的增加,了解衰老至关重要.
- 结合神经成像和表观遗传数据的纵向研究很少.
- 表观遗传衰老,大脑衰老和认知功能之间的关系在很大程度上是未知的.
研究的目的:
- 通过青春期和年轻成年期调查表观遗传衰老的纵向变化.
- 评估表观遗传衰老与大脑衰老之间的关联.
- 检查表观遗传衰老与认知结果之间的联系.
主要方法:
- 使用Illumina EPIC平台进行DNA甲基化评估.
- 用Horvath的表观遗传时钟估计表观遗传年龄,计算表观遗传年龄差距 (EpiAGE).
- 使用结构性MRI计算大脑年龄,使用R (NAPR) 平台进行神经解剖学年龄预测;使用韦克斯勒成人智力量表 (WAIS) 评估认知能力.
主要成果:
- 表观遗传年龄差距 (EpiAGE) 在青春期和年轻成年期表现出相对稳定性.
- 研究期间结束时,更快的衰老速度与EpiAGE相关.
- 较高的阳性EpiAGE与积极的大脑年龄差距有关,在女性中,全尺度智商较低.
结论:
- 表观遗传年龄差距 (EpiAGE) 是青春期和成年早期的一个稳定的个体特征.
- 表观遗传衰老与加速的大脑衰老有很小的关系.
- 在年轻的成年女性中,更高的EpiAGE和更差的表现智商之间发现了特定的关联.
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