骨代谢标志物的异常变化随着年龄的增长在患有脑的儿童中
Wen Xing1, Lin Liang1, Na Dong1
1Department of Clinical Laboratory, Beijing Bo'ai Hospital, China Rehabilitation Research Center, Beijing, China.
Frontiers in pediatrics
|August 18, 2023
概括
骨代谢指标在患有脑 (CP) 的儿童中不同. 与健康儿童相比,关键标记物,如总公原I型N终端 (TPINP) 和β-交叉 (β-CTX) 显示出显著的差异,随年龄而异,但不包括疾病严重程度.
科学领域:
- 儿科 儿科 儿科
- 代谢性骨疾病 代谢性骨疾病
- 神经学 神经学
背景情况:
- 大脑麻 (CP) 与骨健康受损有关,包括骨密度低和骨折风险增加.
- 了解骨代谢障碍对于管理CP的长期健康影响至关重要.
研究的目的:
- 调查骨代谢指标与被诊断为脑的儿童之间的关联.
- 为了比较患有CP的儿童和健康对照者之间的特定骨周转标记物的血清水平.
主要方法:
- 跨截面研究涉及139名儿童 (75名CP,64名对照) 在三个年龄组 (0-7岁).
- 测量了I型全聚原N-终端 (TPINP),N-MID骨素 (OC),β-交叉 (β-CTX),25-氧维生素D (25-OHD) 和副甲状腺激素 (PTH) 的血清水平.
- 患有CP的儿童根据临床亚型进行分类.
主要成果:
- 血清中TPINP和25-OHD的水平随着年龄的增长而下降;β-CTX和PTH随着年龄的增加而增加.
- 与对照组相比,患有CP的儿童表现出较高的TPINP和OC水平 (特定年龄组) 和较低的β-CTX和PTH水平 (特定年龄组).
- 在CP临床亚型之间没有发现骨代谢指标的显著差异.
结论:
- 骨循环标志物和骨代谢指标在患有CP的儿童和健康儿童之间存在显著差异.
- 儿童的年龄会影响这些骨代谢指标,但疾病的严重程度与CP中的水平无关.
- 这些发现凸显了CP儿童的独特代谢概况,表明了潜在的干预目标.
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