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门德尔随机化分析支持肠道微生物群和儿童肥胖之间的因果关系

Qi Li^1,2, Jiawei Gao¹, Jiashun Luo¹

¹School of Medicine, Jishou University, Jishou, China.

Frontiers in pediatrics

|August 18, 2023

概括

儿童肥胖与肠道细菌有关. 阿克尔曼西亚属可能会防止儿童肥胖和高BMI,提供潜在的干预策略.

科学领域:

人类微生物组研究研究
儿科公共卫生儿科公共卫生
遗传流行病学遗传流行病学

背景情况:

儿童肥胖 (CO) 是一个日益严重的公共卫生问题.
肠道微生物群 (GM) 越来越多地与CO有关,但因果关系需要仔细调查.
混因素和反向因果关系需要强大的分析方法.

研究的目的:

使用孟德尔随机化研究肠道微生物群和儿童肥胖之间的潜在因果关系.
确定与儿童肥胖和儿童体重指数 (CBMI) 相关的特定细菌属.
通过复制和反向分析来验证发现并确认因果方向.

主要方法:

利用了微生物组基因组联盟和早期生长遗传学联盟的数据.
应用了多种门德尔随机化 (MR) 方法,包括反变量加权,最大概率,加权中位数和MR-RAPS.
进行复制分析,反向MR和灵敏度分析 (Cochran的Q,MR-Egger,MR-PRESSO,留出一个) 以确保稳定性.

主要成果:

确定了八种细菌属和CO风险 (CO五种,CBMI四种) 之间的诱导性因果关系.
验证并证实了与儿童肥胖相关的三种属:阿克尔曼西亚,肠杆菌和Butyricimonas.
阿克尔曼西亚属表现出一种保护作用,与CO (OR=0.574) 和CBMI (β=-0.172) 负相关.

结论:

门德尔的随机化研究支持肠道微生物群在儿童肥胖中起因作用.
阿克尔曼西亚属似乎对儿童肥胖和高BMI有保护作用.
调查结果表明,阿克克曼西亚是二氧化碳预防和干预策略的潜在目标.

关键词:

门德尔的随机化这种因果关系是因果关系.童年儿童体重指数体重指数儿童肥胖儿童肥胖儿童肥胖我们的肠道微生物群.

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