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Updated: Jul 19, 2025

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设计,合成和评价化酶抗菌前药物,向酸还原酶激活

Ke Liu1, Tao Xiao1, Hongfen Yang1

  • 1Department of Medicinal Chemistry, Center for Natural Products, Drug Discovery and Development (CNPD3), College of Pharmacy, University of Florida Gainesville Florida 32610 USA rhuigens@cop.ufl.edu.

RSC medicinal chemistry
|August 18, 2023
PubMed
概括

开发了新的化氨酸 (HP) 前药,以对抗抗生素耐药性. 这些基于烯的化合物被缩酶 (NTR) 酶激活,释放出对抗耐药细菌有效的强效HP剂.

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