维生素D可以缓解甲状腺功能低下与肝功能障碍相关的症状: 组织学和生物化学证据
Seyed Hamidreza Rastegar-Moghaddam1,2, Mahsan Akbarian3, Arezoo Rajabian4
1Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran.
Heliyon
|August 18, 2023
概括
维生素D可能会保护肝脏免受甲状腺功能低下症造成的损伤. 这项研究发现,维生素D在甲状腺功能低下小鼠中减少了肝损伤标志物和纤维化,这表明抗氧化和抗纤维性益处.
科学领域:
- 内分泌学 在内分泌学.
- 肝病学 肝病学是一种肝病学.
- 营养科学 营养科学
背景情况:
- 甲状腺激素 (THs) 对新陈代谢调节至关重要,它们的缺乏 (甲状腺功能下降) 可以损害肝功能.
- 新兴研究表明,维生素D可能具有抗肝损伤的保护性质.
研究的目的:
- 调查维生素D在减轻与甲状腺功能低下相关的肝损伤方面的潜在保护作用.
- 评估维生素D对肝功能,氧化应激和纤维化在甲状腺功能低下的小鼠模型的影响.
主要方法:
- 40只雄性Wistar大鼠被分为对照组,甲状腺功能低下组 (由PTU诱导) 和两个甲状腺功能低下组,补充维生素D (100和500 IU/kg).
- 评估了肝功能酶 (ALT,AST,ALP),氧化应激标志物 (MDA,SOD,总醇) 和肝纤维化 (马森三色染色).
- 干预持续了6周.干预持续了6周.
主要成果:
- 甲状腺功能低下症显著增加血清肝酶 (ALT,AST,ALP) 和肝纤维化.
- 维生素D的使用显著降低了这些高的酶,并抑制了原纤维的积累.
- 维生素D治疗改善了氧化应激标志物,减少了MDA,增加了SOD活性和总醇含量.
结论:
- 维生素D具有显著的抗氧化和抗纤维性质.
- 维生素D补充剂可以有效地减少肝损伤在甲状腺功能低下的背景下.
- 这些发现凸显了维生素D对甲状腺功能低下症相关肝损伤的治疗潜力.
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