共生细菌,类似免疫的哨兵细胞,以及对病原体的反应,在一个社会虫
Trey J Scott1, Tyler J Larsen1, Debra A Brock1
1Department of Biology, Washington University in St. Louis, St. Louis, MO 63130, USA.
Royal Society open science
|August 18, 2023
概括
细菌内共生体,Paraburkholderia,在社会性虫Dictyostelium discoideum中损害了免疫哨兵细胞. 然而,这些受感染的虫对毒素的耐药性增加,突出显示了复杂的共生关系.
科学领域:
- 微生物学 微生物学
- 交生研究 交生研究
- 社会阿米巴生物学的生物学
背景情况:
- 内生共生生物经常操纵宿主免疫系统以保持持久性.
- 像Dictyostelium discoideum这样的社会虫具有作为免疫系统的哨兵细胞.
- 在Dictyostelium discoideum和Paraburkholderia之间的相互作用是共生的一个模型.
研究的目的:
- 为了研究Paraburkholderia内生生物对Dictyostelium discoideum哨兵细胞的影响.
- 为了确定Paraburkholderia是否影响宿主的免疫功能和毒素耐药性.
- 探索这种细菌内生体与其社会母宿主之间的多方面的关系.
主要方法:
- 在感染和未感染的Dictyostelium discoideum聚合物中量化哨戒细胞的数量和功能.
- 评估受感染和未受感染的D. discoideum对乙基化物和其他病原体的敏感性.
- 在共生与非共生相互作用中对免疫反应和毒素耐药性的比较分析.
主要成果:
- 受感染的D. discoideum表现出哨兵细胞的数量和功能减少.
- 尽管免疫功能受损,但感染的D. discoideum对乙基化物毒性的耐药性增强.
- 在感染和未感染宿主之间没有观察到对非共生病原体敏感性的显著差异.
结论:
- 帕拉伯克持有症似乎干扰了Dictyostelium discoideum的免疫系统.
- 这种内生生物可能会对某些毒素产生保护作用.
- 这项研究加深了对D. discoideum和Paraburkholderia之间复杂的共生动态的理解.
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