激活诱导性T细胞辅助刺激器单独产生抗瘤活性,并与抗PD-1检查点阻塞相结合,产生抗瘤活性

Sapna Yadavilli1, Jeremy D Waight1, Sara Brett2

  • 1GSK, Collegeville, Pennsylvania.

PubMed
概括

用费拉迪利马布单独或与PD-1阻断一起刺激诱导性T细胞成本刺激器 (ICOS),显示出抗瘤潜力. 这种方法激活T细胞,并在临床前模型和先进癌症早期患者研究中证明有效性.

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