PdII-和RuII-pyta复合物的抗菌特性
Annick van Niekerk1, M Cassiem Joseph2, Angela Kavanagh3
1Department of Chemistry and Polymer Science, University of Stellenbosch, Stellenbosch, Private bag X1, Matieland, 7602, South Africa.
Chembiochem : a European journal of chemical biology
|August 18, 2023
概括
基于 (Pd) 和 (Ru) 的新型金属催化剂显示出强大的抗真菌活性,对抗Candida glabrata. 这些金属药物是开发抗微生物药物来打击耐药性的有希望的新来源.
科学领域:
- 药用化学 医学化学
- 发现抗微生物药物 发现抗微生物药物
- 协调化学 协调化学
背景情况:
- 抗菌素耐药性 (AMR) 构成了严重的全球健康威胁,主要原因是过度使用抗生素和缺乏新药开发.
- 金属药物代表了一类未经探索的化合物,具有潜在的抗微生物特性.
- 开放抗微生物药物发现社区 (CO-ADD) 倡议寻找新型化合物来解决AMR.
研究的目的:
- 评估新型 () 和 () 复合物的抗菌潜力. -1,2,3-triazolyl复合物.
- 研究这些金属药物对耐药病原体的抗真菌活性.
- 评估有前途的候选药物的体外和体内疗效和毒性.
主要方法:
- 18种Pd (II) 和Ru (II) 金属复合物的合成和表征.
- 抗微生物敏感性测试,包括确定对Candida glabrata的最小抑制度 (MIC).
- 使用Galleria mellonella幼虫模型进行体内毒性和疗效研究.
主要成果:
- 二复合物,特别是Pd1,对Candida glabrata表现出强烈的抗真菌活性,MIC范围为0.06至0.125μg/mL.
- 与复合物相比, (II) 复合物显示的活性不那么强大.
- 在 Galleria mellonella 的体内研究表明,测试的化合物是无毒的.
结论:
- 帕拉 (Palladium) - 皮里迪尔-1,2,3-醇复合物是有效的抗真菌剂,具有对抗Candida glabrata感染的显著潜力.
- 这些金属药物为开发针对耐药病原体的新抗菌疗法提供了有希望的途径.
- 为了发现抗微生物药物,需要对基于Pd (II) 的金属药物进行进一步的研究.
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