使用免疫细胞死亡来提高免疫检查点抑制剂的抗癌疗效:从基础科学到临床应用
François Ghiringhelli1,2,3,4,5, Cédric Rébé1,2,3
1Cancer Biology Transfer Platform, Centre Georges-François Leclerc, Dijon, France.
Immunological reviews
|August 18, 2023
概括
将免疫检查点抑制剂 (ICI) 与诱导免疫细胞死亡 (ICD) 的疗法结合起来,有望提高癌症治疗疗效. 这种方法增强T细胞活性,调节瘤微环境,克服对ICI的抗性.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 癌症治疗 癌症治疗
背景情况:
- 免疫检查点抑制剂 (ICI) 已经改变了癌症治疗,但由于不响应和耐火性癌症而面临限制.
- 预测生物标志物和组合策略对于提高ICI疗效至关重要.
研究的目的:
- 审查关于将ICI与免疫细胞死亡诱导剂 (ICD) 结合的临床前和临床证据.
- 探索ICD诱导剂如何调节瘤微环境并克服ICI抵抗.
主要方法:
- 临床前研究和临床试验的文献综述.
- 对结合ICI与ICD诱导疗法的研究进行分析.
主要成果:
- 涉及ICI和ICD诱导剂的组合疗法显示出改善治疗结果的潜力.
- 这些组合可以增强T细胞的反应,并通过抑制免疫抑制来调节瘤微环境.
结论:
- 将ICI与ICD诱导剂结合起来是一个有前途的策略,可以提高癌症治疗效率.
- 这种方法可以通过增强抗瘤免疫力和改变瘤微环境来克服对ICI的耐药性.
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