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患有心律失常引起心肌病的患者的心房移除:一个前性的多中心研究
Teba González-Ferrero1,2,3, Marco Bergonti4,5,6, José Nicolás López-Canoa3,7
1Cardiovascular Area and Coronary Unit, University Clinical Hospital of Santiago de Compostela, Santiago de Compostela, Spain.
ESC heart failure
|August 18, 2023
概括
因心律失常引起的心肌病 (AiCM) 影响17.56%的心房动 (AF) 患者接受了切除. 持久性AF和慢性病预测AiCM,在切除后改善,复发率与非AiCM患者相似.
科学领域:
- 心脏病学 心脏病学
- 电力生理学 电力生理学
- 心脏衰竭研究研究
背景情况:
- 心房动 (AF) 可能导致心律失常诱导的心肌病 (AiCM).
- 导管切除 (CA) 是AF的治疗选择,但它对AiCM的影响需要进一步调查.
- 了解AiCM的预测因子和结局对于患者管理至关重要.
研究的目的:
- 研究经过CA的AF患者的临床和生化特征,这些患者发展出AiCM.
- 评估在有或没有AiCM的患者中CA的长期结果.
- 确定AiCM发展和CA后复发的预测因素.
主要方法:
- 对连续AF患者进行CA的前性多中心研究.
- AiCM定义为心力衰竭的发展与AF和≥10%改善左心室喷射分数6个月后的移除.
- 在一小组患者中进行生物标志物分析 (盖莱克-3,FABP4,sRAGE).
主要成果:
- 在769名AF患者中,17.56%患有AiCM.
- 对AiCM的预测因素包括持续性AF,男性性别,左心房体积,QRS宽度,吸烟和慢性病 (CKD).
- 生物标志物 (sRAGE,FABP4,加勒-3) 并没有预测AiCM或复发. 在AiCM组和非AiCM组之间,AF复发率相似 (30.83%对27.77%).
结论:
- 在经过切除的AF患者中AiCM的发展与持续的AF和CKD有关.
- 生物标志物分析没有预测AiCM或复发.
- 患有AiCM的患者从CA中受益,表现出左心室喷射率的改善和与没有AiCM的患者相比,AF复发率相似.
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