儿童不良经历和早期开始使用物质:生存分析
Amy L Meadows1, Justin C Strickland2, S Maela Hyder3
1Department of Psychiatry, College of Medicine, University of Kentucky, Lexington, KY, USA.
International journal of psychiatry in medicine
|August 18, 2023
概括
更高的不良童年经历 (ACE) 与更早开始使用物质有关,包括香烟和处方阿片类药物. 对ACE的早期预防和干预可以降低成年物质使用障碍的风险.
科学领域:
- 精神病学和行为科学
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
背景情况:
- 早期的逆境,特别是不良童年经历 (ACE),是已知的物质使用障碍 (SUD) 的风险因素.
- ACE与更早开始实验和使用物质相关.
- 了解ACE和物质开始的年龄之间的准确关系对于有针对性的干预至关重要.
研究的目的:
- 调查童年不良体验 (ACE) 数量与开始使用物质的年龄之间的关联.
- 为了确定更高的ACE分数是否预测了首次使用物质的早期年龄.
- 利用生存分析来建模ACEs对物质使用启动时间表的影响.
主要方法:
- 招募了107名成年参与者的队列,他们积极使用物质,但没有接受治疗.
- 参与者完成了ACE的评估,并报告了他们第一次使用物质的年龄.
- 使用考克斯的比例危险模型来分析ACE得分与药物开始的年龄之间的关系.
主要成果:
- 该研究发现,较高的ACE得分与早期开始吸烟和非医疗处方阿片类药物的使用之间存在显著的关联.
- 具有较高ACE分数的参与者表现出这些特定物质的早期发病年龄具有统计学意义.
- 开始吸烟的风险比为1.14 (p=0.02),非医疗处方阿片类药物使用的风险比为1.19 (p=0.01) ,每单位增加ACE得分.
结论:
- 这些发现证实了童年不良经历的增加与早期开始吸烟和处方阿片类药物的使用之间存在重大联系.
- 这些结果强调了初级预防策略的重要性,旨在减少儿童时期的ACE.
- 在儿童时期检测到ACE的情况时,查和干预可能对减轻成年后发展物质使用障碍的风险至关重要.
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