一种以香草为基础的多草药配方DuK可以预防雄性鼠肝细胞癌
Meenakshi Gupta1, Hemlata Nimesh1, Anwar L Bilgrami2
1Amity Institute of Pharmacy, Amity University, Noida, Uttar Pradesh, India.
Current cancer drug targets
|August 18, 2023
概括
杜克是一种传统的印度医药,通过保护老鼠肝脏免受化学诱导的癌症,显示出显著的抗癌特性. 它通过减少氧化应激和促进亡来起作用,提供潜在的化学预防益处.
科学领域:
- 药理学 药理学是指药理学的学科.
- 肝病学 肝病学是一种肝病学.
- 癌症研究 癌症研究
背景情况:
- 杜克是一种传统的印度医药,在治疗各种疾病方面有着悠久的历史.
- 肝细胞癌 (HCC) 仍然是一个重大的全球健康问题,需要新的治疗策略.
研究的目的:
- 为了研究杜克的抗癌作用,对大鼠的二甲基尼托拉胺 (DEN) 诱导的肝癌.
- 阐明杜克化学预防作用的潜在机制.
主要方法:
- 在DEN暴露之前和期间,大鼠被给予Duk的剂量各不相同 (75,150,300毫克/公斤/天).
- 在DEN给药后,使用2-氨基乙花 (2-AAF) 促进了肝癌发生.
- 分析了肝功能标志物,氧化应激指标 (SOD,CAT,MDA),组织病理学和与亡相关的蛋白质 (Bid,Caspase-9,Cyclin D).
主要成果:
- 杜克显著减少了DEN和2-AAF诱导的肝损伤,并恢复了正常的肝功能标志物.
- 杜克通过增加超氧化物脱酶 (SOD) 和酶 (CAT) 水平并减少甲 (MDA) 来抵消氧化应激.
- 组织病理学分析显示了恢复的肝脏微架构,免疫组织化学表明杜克通过Bid和Caspase-9诱导亡并减少Cyclin D.的作用.
结论:
- 杜克对大鼠的化学诱导肝癌发生有显著的肝保护作用.
- 杜克的化学预防机制涉及氧化应激的调节和肝功能标志物的恢复.
- 杜克可以通过诱导亡来发挥其保护作用.
更多相关视频
11:36Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms
Published on: May 29, 2020
3.0K
09:03Establishment of Hepatocarcinoma in BALB/c-nu Mice and Investigation of the Therapeutic Effect of the Sanleng Jiashen Formula
Published on: January 26, 2024
403
相关概念视频
02:43Mouse Models of Cancer Study
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
02:43Mouse Models of Cancer Study
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...