儿童患COVID-19相关喘恶化的几率在Omicron波期间更高
Kristina Gaietto1,2, Nicholas Bergum2, Franziska Rosser1,2
1Department of Pediatrics, Division of Pulmonary Medicine, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Pediatric pulmonology
|August 18, 2023
概括
在COVID-19感染期间,Omicron变异浪潮在患有喘的儿童中出现了喘恶化显著增加. 这凸显了不同COVID-19变种如何影响呼吸系统症状,并支持疫苗接种工作.
科学领域:
- 儿科肺病学 儿科肺病学
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 儿童喘恶化是一个重大的公共卫生问题.
- SARS-CoV-2 变种的出现改变了COVID-19 的格局.
- 了解变种对慢性呼吸道疾病的特定影响至关重要.
研究的目的:
- 调查COVID-19变种波浪与儿科喘患者喘恶化之间的关联.
- 为了比较在COVID-19的前-Delta,Delta和Omicron变种浪潮期间喘恶化率.
主要方法:
- 使用西宾夕法尼亚州COVID-19注册表 (WPACR) 的回顾性横截面研究.
- 抽取了患有喘的儿童的数据,比较了Pre-Delta,Delta和Omicron波的结果.
- 进行了多变量逻辑回归分析,以评估与SARS-CoV-2相关的喘恶化.
主要成果:
- 与之前的波浪 (22.6%和26.2%) 相比,Omicron波显示出更高比例的喘恶化 (40.2%).
- 多变量模型表明,在Omicron波期间喘恶化的几率是2.8倍.
- 根据喘严重程度进行调整并没有改变意义,但根据喘控制不佳进行调整却改变了意义.
结论:
- 在SARS-CoV-2感染期间的喘恶化在Omicron变种浪潮期间更为频繁.
- 根据变种,COVID-19的症状和影响有很大差异.
- 这些发现加强了对患有喘的儿童进行疫苗接种和预防措施的重要性.
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