智能手机视频游戏可以改善慢性精神分裂症患者的认知功能:随机对照试验
Shengya Shi1, Shu Cui2, Yitan Yao1
1Department of Psychiatry, Chaohu Hospital of Anhui Medical University, 64 North Chaohu Road, Hefei, 238000, China.
European archives of psychiatry and clinical neuroscience
|August 18, 2023
概括
玩电子游戏显著改善了精神分裂症患者的认知功能,并减少了精神分裂症患者的负面症状. 大脑衍生神经营养因子 (BDNF) 血清水平增加,这表明它是潜在的认知改善生物标志物.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 数字治疗学数字治疗学
背景情况:
- 精神分裂症是一种慢性精神障碍,通常与认知缺陷有关.
- 认知障碍对精神分裂症患者的日常功能和生活质量产生重大影响.
- 需要新的干预措施来解决这一群体的认知功能障碍.
研究的目的:
- 研究基于智能手机的视频游戏在慢性精神分裂症患者中增强认知功能的有效性.
- 探索血清脑源性神经营养因子 (BDNF) 作为潜在的生物标志物用于认知改善.
- 评估视频游戏干预对临床症状和整体功能的影响.
主要方法:
- 一项为期6周的干预研究,涉及60名慢性精神分裂症患者.
- 参与者被随机分配到视频游戏组 (每天1小时,5次/周) 或对照组 (看电视).
- 认知功能使用可重复电池评估神经心理状态 (RBANS) 和Stroop Color和Word测试 (SCWT) 进行评估;临床症状使用PANSS,GAF,GSE,PMGQ和PHQ-9进行评估.
主要成果:
- 与对照组相比,视频游戏组在RBANS总得分上显示出显著的改善.
- 在游戏组中,积极和消极综合征量表 (PANSS) 消极量表和全球功能评估 (GAF) 评分中观察到显著改善.
- 视频游戏组的血清BDNF水平在干预后显著上升,并且与RBANS得分呈正相关.
结论:
- 基于智能手机的视频游戏干预显示出改善慢性精神分裂症患者认知功能的前景.
- 血清BDNF水平可以作为一个有价值的生物标志物来预测这种患者群体的认知增强.
- 这种干预为精神分裂症提供了潜在的辅助疗法,改善了认知和临床结果.
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