免疫疗法在妊娠 trofhoblastic 瘤中的进展
Tong Wang1, Wenxiu Guo2, Xiaochen Ren1
1Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, 107 Wenhua Xi Road, Jinan, 250012, Shandong, People's Republic of China.
Journal of cancer research and clinical oncology
|August 18, 2023
概括
孕期热囊细胞瘤 (GTNs) 通常可以通过化疗治愈,但耐火病例可以从免疫治疗中受益. 针对PD-1/PD-L1的免疫检查点抑制剂显示出对挑战GTN的承诺.
科学领域:
- 妇科瘤学 妇科瘤学
- 免疫治疗是一种免疫疗法.
- 热囊细胞新生体
背景情况:
- 孕期热囊细胞瘤 (GTNs) 通常具有高的化学疗法治愈率.
- 一小部分GTN对传统治疗具有耐火性.
- 免疫疗法为治疗耐火GTN提供了一个有前途的途径.
研究的目的:
- 系统地审查GTN中的免疫微环境.
- 总结目前针对GTN的免疫治疗策略.
- 确定潜在的生物标志物,以改善GTN管理.
主要方法:
- 对GTNs的免疫疗法进行文献综述.
- 在PubMed数据库中搜索相关研究.
主要成果:
- 目前针对GTN的免疫疗法主要使用免疫检查点抑制剂 (ICI).
- 对ICI的关键目标包括编程死亡受体1 (PD-1) 和编程细胞死亡连接体1 (PD-L1).
- 有效的ICI的例子包括阿维卢马布,潘布罗利祖马布和卡梅利祖马布.
结论:
- 免疫检查点抑制剂是GTN的主要免疫治疗方法.
- 需要进一步的研究,以充分阐明GTN中免疫治疗的机制.
- 生物标志物发现对于优化GTN治疗策略至关重要.
更多相关视频
12:55Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care
Published on: February 16, 2015
21.4K
07:46Author Spotlight: Advancing Reproductive Immunology with a Protocol for the Quantitative Evaluation of Endometrial Immune Cells
Published on: October 13, 2023
1.3K
相关概念视频
01:27Tumor Immunotherapy
556
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
556
01:30Cancer Vaccines
400
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
400
02:57Targeted Cancer Therapies
7.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.7K
02:07Tumor Progression
6.4K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.4K