用化学辐射治疗的第四阶段口喉状状细胞癌患者的预测生存模型
Peng Yeh1, Chih-Ming Chang1,2, Li-Jen Liao1,3,4
1Department of Otolaryngology, Far Eastern Memorial Hospital, 21, Section 2, Nan-Ya South Road, Pan Chiao District, 220, New Taipei City, Taiwan.
概括
低治疗前血红蛋白 (Hb) 和高系统性炎症标志物 (SII和SIRI) 与第四阶段口癌患者的生存率较差有关. 这些因素可以帮助预测结果,并指导治疗调整.
科学领域:
- 在瘤学瘤学.
- 癌症研究 癌症研究
- 临床医学 临床医学
背景情况:
- 第四阶段的口腔关癌 presents一个显著的治疗挑战.
- 同时化学辐射与或没有新辅助化疗是一种标准的治疗方法.
- 确定预后因素对于优化患者生存结果至关重要.
研究的目的:
- 为了确定与第四阶段口癌患者的存活率相关的治疗前和治疗后临床因素.
- 评估营养状况和炎症标志物对生存的影响.
- 开发一种用于预测疾病特异性生存率 (DSS) 的预测模型.
主要方法:
- 在2008年至2020年期间接受治疗的128名第四阶段口腔癌患者的回顾性队列研究.
- 对治疗前和治疗后的临床参数进行审查,包括血红蛋白,全身免疫炎症指数 (SII) 和全身炎症反应指数 (SIRI).
- 多变量分析以确定生存的独立预测因素.
主要成果:
- 总体5年生存率为36.72%.
- 治疗前血红蛋白<12 g/dL,治疗前SII≥1751和治疗后SIRI≥261是疾病特异性生存时间 (DSS) 恶化的独立指标.
- 治疗前血红蛋白<12 g/dL,治疗前SII≥1751,治疗后SII≥1690是恶化的无病生存期 (DFS) 的独立指标.
结论:
- 治疗前的血红蛋白,治疗前的SII,治疗后的SII和治疗后的SIRI与第四阶段口癌的存活率显著相关.
- 包含这些因素的名图可以帮助预测存活率.
- 这些发现支持使用这些标记物进行治疗调整和预后评估.
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