入院时的酸盐水平与急性胰腺炎早期死亡率之间的关联
Maya Fischman1, Adi Elias2, Amir Klein3
1Department of Military Medicine, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
Journal of gastroenterology
|August 18, 2023
概括
高酸盐水平在入院时与急性胰腺炎患者的死亡风险增加有关. 在这项研究中,低酸盐水平与死亡率没有显著关联.
科学领域:
- 关键护理医学 关键护理医学
- 胃肠病学 胃肠病学
- 临床化学 临床化学
背景情况:
- 不正常的血清酸盐水平与危急病患者的不良结果有关.
- 关于酸盐在急性胰腺炎中的作用的证据有限且相互矛盾.
- 这项研究调查了摄入酸盐水平与急性胰腺炎结果之间的关联.
研究的目的:
- 为了确定入院时的酸盐水平是否会影响急性胰腺炎的临床过程和结果.
- 评估低酸血症,高酸血症和急性胰腺炎30天死亡率之间的关系.
- 确定酸盐水平作为急性胰腺炎死亡率的潜在预测因素.
主要方法:
- 对被诊断患有急性胰腺炎的成年患者进行了回顾性,单中心的观察性研究.
- 摄入时的酸盐水平分为正常 (2.8-4.5 mg/dL),低 (<2.8 mg/dL) 或高 (>4.5 mg/dL).
- 从2008年1月到2021年6月对1868名患者的分析.
主要成果:
- 高酸盐血症与30天死亡率 (19%) 与正常 (3.4%) 或低 (3.8%) 酸盐水平相比显著更高.
- 多变量分析证实过酸血是早期死亡的独立预测因子 (OR 2.93,p=0.009).
- 低酸血症与30天死亡率没有显著关联 (OR1.13,p=0.6).
结论:
- 住院时的高酸血是急性胰腺炎30天死亡率增加的独立风险因素.
- 摄入酸盐水平可以作为急性胰腺炎的预后标志物.
- 低酸血症似乎不会显著影响这个患者群体的短期死亡率.
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