COVID-19和儿科风湿病学:来自沙特阿拉伯一家领先的高等医疗中心的综合研究
Jubran Alqanatish1,2,3, Abdullah Almojali4,5,6, Abdulmajeed Alfadhel4,5,6
1College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, 14611, Riyadh, Saudi Arabia. qanatishj@mngha.med.sa.
Journal of epidemiology and global health
|August 18, 2023
概括
在患有类风湿性疾病的儿童中,COVID-19感染很常见,大多数儿童康复良好. 然而,未接种疫苗的儿童和服用某些药物的儿童面临更高的住院风险,这强调了疫苗接种的重要性.
科学领域:
- 儿科风湿病学 儿科风湿病学
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 冠状病毒疾病2019 (COVID-19) 流行病对全球健康构成风险,对儿科类类风湿性疾病患者的数据有限.
- 患有风湿性疾病的儿童经常接受免疫调节/免疫抑制疗法,这可能会影响他们的感染反应.
研究的目的:
- 调查COVID-19感染率,临床特征,风险因素和儿科患者的风湿性疾病的结果.
- 为了确定这种脆弱人群中严重的COVID-19结果的特定风险因素.
主要方法:
- 沙特阿拉伯阿卜杜拉国王专门儿童医院 (KASCH) 的回顾性队列研究.
- 2020年3月至2022年3月期间被诊断患有COVID-19的19岁以下类风湿病患者的审查.
- 对临床表现,风险因素和住院/死亡率的分析.
主要成果:
- 在482名儿科风湿病患者中,126名 (26.1%) 感染了COVID-19;没有因素增加了感染风险.
- 发烧和呼吸道症状是最常见的;30%是无症状的. 大多数人康复 (97.6%),但2.38%的人死亡.
- 男性和服用t-DMARD或葡萄糖皮质激素的患者患上住院风险较高. 接种疫苗可以降低住院的风险.
结论:
- 儿童类风湿病患者中COVID-19感染很普遍,结果各异.
- 接种疫苗显著降低了住院的风险. 对于未接种疫苗的患者和服用t-DMARD或葡萄糖皮质激素的患者,警监测至关重要.
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