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Updated: Jul 19, 2025

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FOXA1 O-GlcNAcylation介导的转录开关控制了乳腺癌转移能力

Yajie Liu1, Kairan Yu1, Xiaotian Kong2,3

  • 1School of Life and Pharmaceutical Sciences, Dalian University of Technology, Panjin, China.

Science advances
|August 18, 2023
PubMed
概括

通过改变基因转录,FOXA1的O链接N-乙糖胺修饰 (O-GlcNAcylation) 驱动乳腺癌转移. 抑制FOXA1 O-GlcNAcylation抑制了瘤的生长和扩散,这表明了一个新的治疗点.

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