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Updated: Jul 19, 2025

Novel Protocol for Generating Physiologic Immunogenic Dendritic Cells
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CD137 (4-1BB) 需要物理相关的cIAP来进行信号传导和抗瘤作用

Javier Glez-Vaz1,2, Arantza Azpilikueta1,2, María C Ochoa1,2,3,4

  • 1Program of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Spain.

Science advances
|August 18, 2023
PubMed
概括

细胞亡抑制蛋白 (cIAP) 对CD137 (4-1BB) 信号传递至关重要,增强T细胞反应和抗瘤作用. 它们的完整性对于基于CD137的免疫疗法和CAR T细胞疗效至关重要.

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