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Updated: Jul 19, 2025

Chemoselective Modification of Viral Surfaces via Bioorthogonal Click Chemistry
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Chemoselective Modification of Viral Surfaces via Bioorthogonal Click Chemistry

Published on: August 19, 2012

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阿尔基因作为一种潜伏的弹头,以共同向SARS-CoV-2主蛋白酶

Chau Ngo1, William Fried2, Saba Aliyari3

  • 1Department of Chemistry and Loker Hydrocarbon Research Institute, University of Southern California, Los Angeles, California 90089, United States.

Journal of medicinal chemistry
|August 18, 2023
PubMed
概括

研究人员发现,类可以作为潜伏弹头,共同抑制SARS-CoV-2主要蛋白酶 (Mpro),这是病毒复制的关键酶. 这一发现为开发有效的COVID-19抗病毒疗法提供了一个有希望的新策略.

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Acidity of 1-Alkynes02:42

Acidity of 1-Alkynes


The acidic strength of hydrocarbons follows the order: Alkynes > Alkenes > Alkanes. The strength of an acid is commonly expressed in units of pKa — the lower the pKa, the stronger the acid. Among the hydrocarbons, terminal alkynes have lower pKa values and are, therefore, more acidic. For example, the pKa values for ethane, ethene, and acetylene are 51, 44, and 25, respectively, as shown here.
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All meta-directing substituents are deactivating groups. These substituents withdraw electrons from the aromatic ring, making the ring less reactive toward electrophilic substitution. For example, the nitration of nitrobenzene is 100,000 times slower than that of benzene because of the deactivating effect of the nitro group. The first step in an electrophilic aromatic substitution is the addition of an electrophile to form a resonance-stabilized carbocation. The energy diagrams for...
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