墨西哥裔美国成年人的内皮功能障碍和心脏代谢风险因素:卡梅伦县西班牙裔队列
Enrique Garcia-Sayan1, Miryoung Lee2, James R Stone3
1Department of Medicine, Section of Cardiology, Baylor College of Medicine, Houston, Texas.
The American journal of cardiology
|August 18, 2023
概括
心血管疾病风险因素,如高血压和代谢综合征,对年长和年轻的墨西哥裔美国人的血管功能产生不同影响. 识别这些因流动介导扩张 (FMD) 障碍的年龄特异性决定因素,可以帮助预防未来的心血管事件.
科学领域:
- 心血管研究研究心血管研究
- 血管生物学 血管生物学
- 健康差异 在健康上的差异
背景情况:
- 脑内皮功能障碍,通过手臂流介导扩张 (FMD) 来衡量,是心血管疾病 (CVD) 的早期指标.
- 以前的研究将糖尿病,肥胖和代谢综合征聚集与年轻西班牙裔患者的动脉样硬化有关.
- 墨西哥裔美国人面临心血管疾病的高负担,需要研究早期检测和预防策略.
研究的目的:
- 在无症状的墨西哥裔美国人的基于人口的样本中识别口热反应受损的决定因素.
- 探索心脏代谢生物标志物和口炎之间的年龄相关联系.
- 在高风险族群中为心脏病预防提供有针对性的干预信息.
主要方法:
- 对来自卡梅伦县西班牙裔群体的960名无症状的墨西哥裔美国人的横截面研究.
- 评估心脏代谢生物标志物和手臂流介导扩张 (FMD).
- 性别特定的口病中位数值对参与者进行了分类;根据年龄分层的逻辑回归分析 (<55岁和≥55岁) 评估了与低口病的生物标志物相关性.
主要成果:
- 低口病与年龄较大,内脏脂肪组织较高,静脉血压,血葡萄糖和代谢综合征有关.
- 在老年人 (≥55岁) 中,男性性别,高血压和糖尿病前期与低口病有显著联系.
- 在年轻的成年人中 (<55岁),高低密度脂蛋白和代谢综合征与低口病有显著的关联.
结论:
- 心脏代谢风险因素显示,在没有先前心血管疾病的墨西哥裔美国人中,年龄依赖的关联与受损的口炎.
- 高血压和糖尿病前期是老年人的关键问题,而高的LDL和代谢综合征对年轻人来说至关重要.
- 根据特定年龄的风险因素量身定制心脏病预防策略,可以减少这种脆弱人群中心脏病的发生.
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