产前空气污染,母亲的免疫激活,以及自闭症谱系障碍
Xin Yu1, Md Mostafijur Rahman2, Sarah A Carter3
1Spatial Science Institute, University of Southern California, Los Angeles, CA, USA.
Environment international
|August 18, 2023
概括
母亲免疫激活条件和产前暴露于细颗粒物 (PM2.5) 独立地与儿童自闭症风险增加有关. 然而,这项研究没有发现证据表明这些因素相互作用,进一步提高自闭症谱系障碍 (ASD) 风险.
科学领域:
- 环境健康 环境健康
- 流行病学 流行病学
- 发育儿科 发育儿科
背景情况:
- 自闭症谱系障碍 (ASD) 的风险受遗传和环境因素的影响.
- 产前暴露于细颗粒物 (PM2.5) 和母体免疫激活 (MIA) 被怀疑是导致ASD的因素.
- 这些环境因素可能有共同的生物学途径,这表明对ASD风险的潜在协同作用.
研究的目的:
- 调查MIA相关疾病和产前PM2.5暴露与ASD风险之间的相互作用.
- 检查MIA和PM2.5组件对自闭症发展的综合影响.
主要方法:
- 一项基于人口的队列研究,对加利福尼亚州南部的318,751对母亲和孩子进行了研究.
- 通过2001年至2014年间出生儿童的电子医疗记录确定了ASD诊断.
- 使用考克斯回归模型评估和分析了MIA条件 (感染,高血压,喘,自身免疫性疾病) 和平均产前PM2.5暴露.
主要成果:
- 自闭症风险与MIA相关的疾病 (感染,高血压,孕产妇喘,自身免疫性疾病) 有关.
- 产前增加的PM2.5暴露及其成分 (BC,OM,NO3-,SO42-) 也与更高的ASD风险有关.
- 在MIA条件和PM2.5暴露在ASD风险之间没有发现统计学意义上的相互作用.
结论:
- 母亲免疫激活条件和产前PM2.5暴露是ASD的独立风险因素.
- 该研究没有发现MIA和PM2.5暴露对自闭症谱系障碍风险的协同效应的证据.
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