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与瘤相关的巨细胞在HCC侵袭边缘触发MAIT细胞功能障碍

Benjamin Ruf1, Matthias Bruhns2, Sepideh Babaei3

  • 1Gastrointestinal Malignancy Section, Thoracic and Gastrointestinal Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

Cell
|August 18, 2023
PubMed
概括

粘膜相关的不变T细胞 (MAIT) 在肝癌中具有功能障碍,无法透到瘤中. 向与MAIT细胞相互作用的瘤相关的巨细胞可以恢复它们的抗癌活性.

关键词:
编码美国一个MAIT单元其他国家/地区aPD-1/aPD-L1 其他免疫疗法内在的类似T细胞粘膜相关的不变T细胞瘤免疫微环境与瘤相关的巨细胞

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