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由细胞组装的细胞外矩阵制成的生物的开发和表征

Paul Borchiellini¹, Adeline Rames¹, François Roubertie^2,3

¹Univ. Bordeaux, INSERM, BIOTIS, UMR1026, Bordeaux F-33000, France.

|August 18, 2023

概括

研究人员从细胞组装细胞外矩阵 (CAM) 带开发了新的生物,用于血管修复. 与合成材料相比,这些CAM提供了优越的机械性能和生物相容性,对心血管外科手术显示出希望.

科学领域:

生物材料科学生物材料科学
血管外科血管外科
组织工程是组织工程.

背景情况:

像ProleneTM这样的合成是血管修复的标准,但会引发不良的免疫反应.
植入的合成材料可以被降解,封装或被人体排出.
对于心血管程序,需要生物相容和机械坚固的接材料.

研究的目的:

开发和评估使用细胞组装细胞外矩阵 (CAM) 带进行心血管手术修复的创新生物.
评估基于CAM的的机械性能和体内性能.
为了比较CAM线与传统合成线的疗效.

主要方法:

基于CAM的带是机械制造和特征的.
使用不同宽度的水合或扭曲/干燥的CAM带构建生物.
进行了ex vivo机械测试 (抗爆,透性) 和ex vivo大动脉解剖.
在活体中,在绵羊中进行了状动脉解,通过声谱评估结果.

主要成果:

基于CAM的生物 sutures比ProleneTM sutures具有较低的透性和更高的抗破性.
在羊的体内植入证明了与标准血管外科手术技术的兼容性.
声谱证实没有血栓形成,并在解剖后10分钟内实现了完美的平衡,没有血液泄漏.

结论:

基于细胞组装细胞外矩阵 (CAM) 的带代表了用于血管修复的合成的可行替代品.
这些新的生物显示出出色的机械性能和生物相容性.
这些发现支持CAM合在心血管应用中的临床相关性和有效性.

关键词:

这是一种解剖解剖学.生物接生物接细胞组装的细胞外矩阵.人类织品人类织品

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