前带状皮质的Janus效应:疼痛和情绪
Sarah H Journée1, Victor P Mathis1, Clémentine Fillinger1
1Centre National de la Recherche Scientifique, Université de Strasbourg, Institut des Neurosciences Cellulaires et Intégratives, Strasbourg, France.
Neuroscience and biobehavioral reviews
|August 18, 2023
概括
前带带皮质 (ACC) 对于处理慢性疼痛和情绪障碍至关重要. 最近的临床前研究揭示了ACC变化如何导致疼痛.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 疼痛研究 疼痛研究
背景情况:
- 前带带皮层 (ACC) 与神经和精神疾病有关.
- 该ACC对于情绪,自主调节,疼痛处理,注意力,记忆和决策至关重要.
- 越来越多的证据将ACC与疼痛的情感方面联系起来,以及与焦虑和抑郁症的并发症.
研究的目的:
- 审查最近关于ACC在慢性疼痛情绪成分和后果中的作用的临床前研究.
- 阐明ACC在情绪和疼痛处理中的功能.
主要方法:
- 审查最近的临床前研究.
- 在ACC和相关电路中分析疼痛诱导的电生理学,分子和解剖学变化.
主要成果:
- 该ACC是慢性疼痛的情绪处理的关键区域.
- 疼痛在ACC中诱导了显著的电生理学,分子和解剖学变化.
- 慢性疼痛也会影响ACC的相关电路.
结论:
- 在慢性疼痛的情感后果中,ACC起着重要作用.
- 需要进一步的研究才能充分理解ACC在情绪和疼痛处理中的参与.
- 临床前发现提供了对疼痛和情绪中ACC功能的机制性理解.
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