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通过局部药物输送调节头发生长,并通过STAR颗粒增强

Mi Ran Woo¹, Mark R Prausnitz²

¹School of Chemical & Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA, USA; College of Pharmacy, Hanyang University, 55 Hanyangdaehak-ro, Sangnok-gu, Ansan 15588, South Korea.

Journal of controlled release : official journal of the Controlled Release Society

|August 18, 2023

概括

星粒子创造皮肤微孔,以增强药物输送,以调节头发生长. 这种新型的微针技术改善了局部氧化和阿西克洛维尔的吸收,在临床前的头发生长研究中显示出有前途的结果.

科学领域:

生物材料工程生物材料工程
皮肤病学皮肤病学
药理学药理学是一个学科.

背景情况:

局部发育治疗由于皮肤透性差而面临生物可用性挑战.
微针技术提供了一种潜在的解决方案,以增强通过皮肤递送药物.

研究的目的:

调查STAR颗粒 (带有微针的毫米大小的陶颗粒) 在增强头发生长药物的皮肤透性的有效性.
评估STAR颗粒对局部输送和米诺克西迪尔和阿西克洛维尔的头发生长调节效应的影响.

主要方法:

优化了STAR粒子的设计和制造.
使用猪皮的ex vivo研究来评估皮肤透性的变化.
在老鼠体内进行实验,以评估药物输送和头发生长的影响.
临床和组织学评估皮肤刺激和不良影响.

主要成果:

在ex vivo模型中,STAR颗粒显著增加了皮肤对米诺西迪尔和阿西克洛维尔的透性,超过三倍.
在体内研究表明,两种药物在老鼠的局部输送得到了改善.
通过STAR颗粒治疗,可以调节头发的生长 (用米诺西迪尔促进,用阿西克洛维尔抑制) 并没有观察到皮肤刺激.

结论:

通过创建皮肤微孔,STAR颗粒有效地增强局部药物输送.
这项技术可以提高毛发生长调节剂 (如米诺西迪尔和阿西克洛维尔) 的疗效.
STAR粒子代表了一种安全有效的方法,用于增强毛发生长调节的局部治疗方法.

关键词:

阿西克洛维尔 (acyclovir) 是一种药物.调节头发的生长调节头发的生长微针微针的使用方法这种药物是米诺西迪尔 (Minoxidil).这就是星粒子.皮肤的透性局部药物输送局部药物输送

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