从可注射的酸盐水凝中可控制地释放氧化
Guangbin Zheng1, Rulin Li2, Peixuan Wu1
1Key Laboratory of Advanced Materials of Tropical Island Resources of Ministry of Education and School of Chemical Engineering and Technology, Hainan University, Haikou, Hainan 570228, China.
International journal of biological macromolecules
|August 18, 2023
概括
释放氧化 (NO) 的可注射水凝是使用藻酸盐和SNAP供体开发的. 这些新材料显示出显著的抗菌活性和生物医学应用的潜力.
科学领域:
- 生物材料科学 生物材料科学
- 药物输送系统 药物输送系统
- 纳米技术纳米技术
背景情况:
- 控制的氧化 (NO) 释放对于生物医学应用至关重要.
- 可注射的无释放材料是一个尚未探索的领域.
- 现有的材料缺乏足够的注射性和控制的NO释放.
研究的目的:
- 为了合成和描述新的可注射NO释放水凝.
- 为了评估这些水凝的NO释放动力学和抗菌疗效.
- 评估开发的水凝的物理性质,包括胀和降解.
主要方法:
- 通过使用D-(+) -gluconate δ-lactone的酸盐和离子在现场交叉连接,合成可注射水凝.
- 将S-nitroso-N-乙-青胺 (SNAP) 作为氧化 (NO) 捐赠物的加入.
- 使用红外和SEM光谱学进行表征;评估NO释放,抗菌活性,胀和降解.
主要成果:
- 成功合成了可注射的NO释放水凝,可调节NO释放长达47小时.
- 实现高抗菌率高达95%对大肠杆菌和金黄色葡萄球菌.
- 证明了水凝矩阵的优良吸水,胀行为和降解性能.
结论:
- 开发的无释放注射水凝对生物医学应用具有有前途的特性.
- 可调节的NO释放和强大的抗菌活性使它们适合用于感染控制.
- 对其体内表现的进一步研究是必要的,以获得临床转化.
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