阿佐克西斯特罗宾对folsomia candida的多代和跨代影响
Marija Kovačević1, Nikolina Stjepanović1, Luca Zelić1
1University of Osijek, Department of Biology, Cara Hadrijana 8/A, HR-31000, Osijek, Croatia.
Environmental pollution (Barking, Essex : 1987)
|August 18, 2023
概括
多代毒性测试显示,阿佐克西斯特罗宾 (AZO) 对土壤生物体带来了低估的风险. 即使在低剂量中,AZO也严重影响生殖,并导致代际氧化应激,突出显示需要更新毒性指南.
科学领域:
- 环境毒理学环境毒理学
- 生态毒理学 生态毒理学
- 土壤科学 土壤科学
背景情况:
- 标准毒性测试往往忽略了污染物的多代 (MG) 和跨代 (TG) 影响.
- 土壤生物面临各种污染物的长期暴露,需要研究长期影响.
研究的目的:
- 评估阿佐克西斯特罗宾 (AZO) 对福尔索米亚候选菌 (F. candida) 三代多代的毒性影响.
- 评估AZO对土壤无脊椎动物的繁殖,氧化应激和能源预算的影响.
主要方法:
- 生物化学和人口水平生物标志物的应用,以评估AZO毒性.
- 在F0,F1和F3世代进行生殖测试和氧化应激指标 (SOD,脂质损伤) 的测量.
- 分析全身能源预算 (WBEB) 和能量储备比例.
主要成果:
- 代际EC50值显著下降,表明对AZO的敏感性增加.
- 在高AZO度下,F1世代的幼虫数量减少和生殖功能衰竭.
- 在所有代人中观察到持续的氧化应激和脂质损伤,F1受影响最大.
结论:
- 标准毒性测试可能低估了阿佐克西斯特罗宾对土壤生物种群的风险.
- 多代毒性测试对于准确的环境风险评估至关重要,应该补充当前的指南.
- 暴露于AZO会产生跨代影响,影响后代的生殖和生理反应.
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