用于吸入的干粉配方需要较小的空气动力直径,以便在高空使用
Ya Xu1, Huiyang Li1, Nan Sun2
1School of Pharmacy, Xuzhou Medical University, Xuzhou 221009, China.
Journal of pharmaceutical sciences
|August 18, 2023
概括
由于低压,干粉配方 (DPF) 在高海拔地区效果较差. 较小的空气动力学直径的DPF可以在低压环境中改善肺部沉积和高空肺水 (HAPE) 治疗.
科学领域:
- 药理学 药理学是指药理学的学科.
- 生物医学工程 生物医学工程
- 呼吸系统医学 呼吸系统医学
背景情况:
- 高海拔肺 (HAPE) 在低压,高海拔环境中对健康构成重大风险.
- 干粉配方 (DPF) 提供了一个有前途的药物输送方法,但在低压吸入方面面临挑战.
- 了解和优化在降低大气压下在呼吸道中的DPF沉积对于有效的HAPE治疗至关重要.
研究的目的:
- 为了研究低大气压对DPF肺部沉积的影响.
- 确定粒子特性如何影响DPF在低压条件下的吸入能力和肺部沉积.
- 开发和验证优化DPF,以便在高海拔地区有效处理HAPE.
主要方法:
- 计算流体动力学 (CFD) 与离散相模型相结合,用于模拟在不同空气压力和粒子特征下的DPF沉积.
- 使用喷雾干燥来制备具有可控空气动力学直径 (0.66,0.98和2.00微米) 的DPF.
- 在小鼠体内研究评估了低压环境中的DPF吸入能力,并在HAPE模型中评估了优化DPF的治疗效果.
主要成果:
- CFD模拟表明,大气压降低显著降低了DPF肺部沉积,较大的颗粒 (∼2.0微米) 在0.5 atm时无法到达下呼吸道.
- 降低DPF的物理直径,密度,从而降低其空气动力学直径,会在低压条件下增强肺部沉积.
- 在小鼠的实验结果证实,较小的空气动力学直径粉末 (0.66和0.98微米) 与较大的粉末 (2.00微米) 相比,可以实现更好的肺部沉积,并更有效地改善HAPE进展.
结论:
- 高海拔地区固有的低大气压阻碍了传统DPF的肺部沉积.
- 用更小的空气动力学直径设计的DPF显示出提高了吸入效率,并在低压环境中改善了HAPE治疗的治疗结果.
- 优化DPF的空气动力学特性对于有效的药物输送和高海拔HAPE管理至关重要.
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