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Updated: Jul 18, 2025

Using the E1A Minigene Tool to Study mRNA Splicing Changes
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神经元SAM68差异调节了替代的最后一个外子拼接,并确保了正确的突触发育和功能

Mohamed Darwish1, Masatoshi Ito2, Yoko Iijima3

  • 1Division of Basic Medical Science and Molecular Medicine, Department of Molecular Life Science, School of Medicine, Tokai University, Kanagawa, Japan; Department of Biochemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt.

The Journal of biological chemistry
|August 18, 2023
PubMed
概括

在神经元中,SAM68调节了替代的最后一个外因子 (ALE) 拼接,影响了突触发育. 异常拼接的protocadherin-15 (Pcdh15) 创建可溶性形式,破坏突触功能.

关键词:
3",UTR"可以使用.艾利·艾利 (ALE) 是一个时间 时间 时间 时间 时间在PCDH15中.这是一种RNA结合蛋白.这就是SAM68的原因.替代性拼接是一种替代性的拼接.胺黄油酸 (GABA) 是一种胺黄油酸.神经发育的神经发育突触突触是指突触中的突触.

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