在渐进的超核性麻中,长期潜在的运动皮质可塑性受损
Makoto Honda1, Takahiro Shimizu1, Shotaro Moriyasu1
1Division of Neurology, Department of Brain and Neurosciences, Faculty of Medicine, Tottori University, Yonago, Tottori, Japan.
概括
长期强化 (LTP) 诱导在渐进性上核性麻 (PSP) 中受损. 运动皮层中LTP降低与勃拉迪基尼西亚严重程度相关,这表明PSP患者的运动皮层功能障碍.
科学领域:
- 神经科学是一个神经科学.
- 发动机控制器的控制器
- 神经生理学 神经生理学
背景情况:
- 渐进性超核性麻 (PSP) 是一种影响运动控制的神经退行性疾病.
- 了解PSP中运动缺陷的神经生理基础对于开发向疗法至关重要.
研究的目的:
- 为了研究长期增强 (LTP) 效应在PSP患者的初级运动皮质 (M1).
- 探索M1 LTP与临床特征,特别是运动症状之间的关系.
主要方法:
- 四脉冲刺激 (QPS) 用于诱导18名PSP患者和17名健康对照 (HC) 的M1中的LTP效应.
- 用短间隔内皮层抑制 (SICI),内皮层促进 (ICF) 和短间隔内皮层促进 (SICF) 来评估皮层刺激性.
- 分析了LTP类效应,皮质刺激性和临床评分 (例如,UPDRS-III) 之间的相关性.
主要成果:
- 与HC相比,PSP患者的LTP类效应显著减少.
- 降低的LTP与统一帕金森病评分表第三部分 (UPDRS-III) 评分负相关,特别是布拉迪基尼西亚.
- 在PSP中,SICI异常减少,而ICF和SICF与对照没有差异. 没有与临床特征相关的皮层刺激性参数.
结论:
- 在PSP中,运动皮层LTP诱导受损.
- 运动皮质LTP的程度可以作为布拉迪基尼西亚严重程度的生物标志物.
- 运动皮层功能障碍,特别是LTP受损,可能导致PSP的运动症状.
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