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Updated: Jul 18, 2025

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
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Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs

Published on: May 15, 2019

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列纳利多米德衍生物和向蛋白解的嵌合体用于控制新基质降解

Satoshi Yamanaka1,2, Hirotake Furihata1,3, Yuta Yanagihara4

  • 1Division of Cell-Free Sciences, Proteo-Science Center, Ehime University, Matsuyama, 790-8577, Japan.

Nature communications
|August 18, 2023
PubMed
概括

修改后的莱纳利多米德选择性降解癌症驱动蛋白质,增强向蛋白质降解. 这一突破为多发性骨髓瘤和5q骨髓质疏松综合征提供了更强大的抗癌效应.

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